Depression: Lack of affect and motivation due to endogenous (i.e. genetic) and exogenous (i.e. environmental) causes. Often caused by the unwise realization that we will be overtaken by death and taxes, that our race is doomed to extinction, and that the sun will explode, pulverizing us into ashes that will in turn be sucked into a black hole. Luckily, this feeling can be cured by the wise realization that Thursday is bowling night.
